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Mechanism of Action

Kyleena® IUD acts locally in the uterus1

Kyleena works locally to prevent pregnancy


  • The local mechanism by which continuously released LNG contributes to contraceptive effectiveness of Kyleena has not been conclusively demonstrated


Studies of Kyleena and similar LNG IUS prototypes have suggested several mechanisms that prevent pregnancy:


  • Thickening of cervical mucus preventing passage of sperm into the uterus
  • Inhibition of sperm capacitation or survival
  • Alteration of the endometrium


IUS=intrauterine system; LNG=levonorgestrel.

Kyleena® (levonorgestrel-releasing intrauterine system) 19.5 mg IUD mechanism of action graphic.


Kyleena cannot be used for post-coital contraception or as an emergency contraceptive.1

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